Master biochemist Peter J. Passalacqua, born in Sicily, was a school-aged child when he came to the U.S. with his family to escape the devastation left by WWII. It didn’t take long for his teachers to recognize his rare intellectual gifts and move him ahead rapidly at school. Passalacqua loved school—especially science subjects and anything to do with math. Outside of school, he loved playing sports and helping his parents grow flowers and vegetables in the family garden.

Passalacqua’s powerful attraction to science eventually connected most strongly with biochemistry—the structure, composition, and chemical reactions of substances in living organisms, including their functions and ways to control them. Biochemistry is the meatiest of all the basic sciences. It encompasses 14 areas of focus, including structural biochemistry, enzymology, metabolic biochemistry, immunochemistry, protein chemistry, biochemical pharmacology, neurochemistry, and clinical biochemistry. Because Passalacqua was an unusually passionate and life-long learner, he did not do what biochemists normally do. Instead of choosing his favorite area to concentrate on—he gradually became an expert in all 14 of them. So he pursued his graduate education in a way that gave him unusual breadth and depth. And his professional goal—what most excited him—was to develop innovative, helpful healthcare and cosmetic products.

Passalacqua achieved his youthful dream. He rose to the top of his field at a young age, creating products and managing extensive manufacturing operations for some of the world’s largest and most influential corporations. But he found himself not aligned with industry decision-making based on financial benefit instead of people’s health benefits. And he eventually felt compelled to pursue his own path. 

Passalacqua’s desire to use his exceptional skills in biochemistry to advance health-restoring tools was as vibrant as ever. But now he would pursue this in the professional lab he had built at home, guided by his credo: “Our vision is to further knowledge for the benefit of humanity.” 

And there was one more factor. Because Passalacqua was not your typical master biochemist, and had by then fully mastered all 14 disciplines within biochemistry, his exceptional intellect did what came naturally. He had begun to integrate all of these systems—and as he progressed, a uniquely complete picture of how our bodies work gradually emerged.

This produced Passalacqua’s transformative realization—that how the body works in health, disease, and injury is NOT what everyone has always thought.

The conventional view of disease and injury defines and treats specific problems. And we know that many treatments have difficult side effects, and/or are only partially effective, and/or take a lot of time to work. We also know that many health challenges still have no effective treatment at all. 

What did Passalacqua see that no one else had? First, he recognized that the body contains a built-in mechanism for healing. When it’s fully equipped to act, it restores and repairs—quickly, completely, and without side effects. And second, he knew exactly what this mechanism is. It involves our mitochondria. These microscopic organelles richly populate almost all of our cells, and are known to produce our energy from the food we eat. A tiny cadre of scientists have recently learned that they actually do a great deal more. But it is only Passalacqua who has realized the full extent of what mitochondria actually do—that they govern the health of the cells they are in. Healthy mitochondria maintain healthy cells. Severe or chronic illness and significant damage reflect mitochondria that have lost their tools for keeping their cells healthy. And restoring their health will restore their ability to make their cells healthy—and keep them that way.

Passalacqua’s next challenge: find an effective and biologically friendly way to restore dysfunctional mitochondria’s missing tools. Then let them do their job—and HEAL. Naturally. Rapidly. And without side effects. 

Passalacqua turned to the plant world. His life-long love of his garden and the plant world had led him to recognize the close relationship between plants and people. It’s no accident that plants—botanicals—were the exclusive medicines for humans until the relatively recent creation of pharmaceuticals. And for 80% of the world’s population, botanicals are still the primary form of healthcare. 

The plants that Passalacqua chose to work with are aloe and oat.

The Situation

Every year, 1.6 million people with diabetes in the US develop their first foot ulcer. (Globally, this annual number is 18.6 million diabetes patients.) Foot ulcers are the feared end result of a complex chain reaction that begins with the oxidative stress caused by hyperglycemia, the high glucose levels that are the defining sign of diabetes. Treatment for these foot ulcers is extremely costly and extremely inadequate. Up to 25% never heal, two-thirds take more than a year to heal, and more than half of healed ulcers recur. Because diabetes also compromises the immune system’s ability to fight infections, 60% of new foot ulcers eventually become infected. Then treatment effectiveness diminishes even further. Roughly 15% lead to death. About 20% of moderate to severe infections eventually require amputation: part or all of the patient’s foot, or the entire lower leg. Post-amputation, the risk of death rises steeply over the first 5 years.

In the US, a limb is amputated due to diabetes every 3 minutes and 30 seconds. (Think about how many people suffered an amputation while you’ve been reading this.) And the Diabetes Research Institute Foundation warns that “type II diabetes is increasing at an alarming rate in the US.” 

Crescel Is Rewriting This Reality

Wherever it has been used around the world, Crescel has radically altered these numbers and erased the feared consequences of amputation and death. In a pilot study—in which patients simply applied Crescel cream twice a day—the patients with the earliest stage (out of 4 stages) foot ulcers were fully healed in just 1 week. Those with Stage II ulcers were completely healed by 4 weeks or less. And impressively, observing these patients for an extended time after healing showed no lesion recurrence, and no new ulcers in the treated area. So not only were these treatment-resistant ulcers fully and rapidly healed, but the ulcer-forming potential in the surrounding skin had been normalized. 

Healing Severe Diabetic Foot Ulcers

Here are 2 severe, deep ulcers, all slated for amputation if Crescel failed to have a substantial impact. The outcome in each case was complete healing. The expansive foot ulcer fully healed in 5 months, preventing amputation of the patient’s foot. The heel ulcer healed in less than 3 months, avoiding loss of the patient’s heel. For both patients, full neurosensory function was restored, there were no side effects, and there was no recurrence.

Bedsores—also called pressure ulcers—are a threat to people who are bedridden or chair-bound, because their ability to change their body position is very limited. The sustained pressure on vulnerable body areas reduces bloodflow to the skin there, and breakdown of that area of skin and the tissue below it is likely to follow. Skin covering bony areas is most at risk: heels, ankles, hips, tailbone. With conventional treatments, if all goes well, early-stage pressure ulcers (Stages 1-2) can heal in 2-3 weeks. But some return and often progress, others do not heal and continue to progress, and some rapidly advance to Stages 3-4. Infection is a constant threat. And people who develop a Stage 4 bedsore face a 70% risk of dying within 180 days after the pressure ulcer appears. 

Crescel can transform this threatening reality. Both patients shown below developed pressure ulcers in their tailbone area. The early-stage ulcer was almost fully healed within 6 days. The other patient had 2 Stage-4 tailbone ulcers. Improvement was rapidly apparent, and by 10 months of twice-daily Crescel application, one bedsore was fully healed. The other was very minimal, and no longer a threat to surrounding muscle and bone.

Crescel has shown its ability to act rapidly on burns and other traumatic damage. It not only heals but also supports the restoration of normal form and function. And it does all of this without side effects. These photos illustrate several typical results after applying Crescel twice a day. A severely disfiguring facial wound healed in only 4 weeks, with normal appearance restored. The partially severed thumb fully regenerated and healed in less than 6 weeks. And with both of these serious injuries, full function was restored and there were no treatment side effects.

Crescel works to restore normal skin. It does this rapidly and with absolutely no side effects. And Crescel is safe and effective for all ages (including infants) and skin types. Results can be dramatic, and sometimes life-changing. One example includes disfiguring skin conditions that have failed to respond to all existing treatments, sometimes at significant cost and suffering. Another example is Crescel’s ability to replace immunomodulating treatments for life-restricting skin diseases such as moderately severe and severe psoriasis and eczema. The success of these immunomodulating treatments comes at the cost of susceptibility to infections and infectious diseases. Crescel’s healing benefits do not incur side effects. 

These patient photos illustrate 2 typical success stories from simply applying Crescel twice a day. A young woman’s severe disfiguring rash—that had only worsened during 2 years of hospital-based treatment—was fully healed after 5 months of Crescel-only treatment. It did not recur. The young woman with severe treatment-resistant papular acne had experienced only short-lived improvements during 8 years of the range of medical and herbal treatments. After switching to Crescel-only treatment, she was clear in 16 days—and remained clear.