Many Crescel users report visible improvements within the first week when used as directed. For best results, apply Crescel Skin Renewal Cream twice daily as part of your daily skincare routine. Individual results will vary depending on your skin type and the severity of their rosacea. While many people notice improvements sooner, we recommend allowing up to 12 weeks to experience the full benefits demonstrated in the published clinical study.

In the published randomized, controlled, double-blinded clinical study, meaningful improvements were observed early in treatment and continued throughout the 12-week evaluation period.

By Week 12, Crescel^® Skin Renewal Cream reduced facial redness (erythema) by 54% compared with 23% for the standard-of-care comparator and reduced inflammatory lesions by 74% compared with 17%.

A published randomized, controlled, double-blinded clinical study compared Crescel Skin Renewal Cream with the standard-of-care prescription therapy, MetroCream® (0.75% metronidazole cream) used alongside CeraVe® Daily Moisturizing Lotion, in adults with mild, moderate, and severe rosacea.

After 12 weeks:

• 54% reduction in facial redness (erythema) compared with 23% for the standard-of-care comparator.

• 74% reduction in inflammatory lesions (papules and pustules) compared with 17% for the standard-of-care comparator.

• Superior clinical performance across both primary endpoints.

• Exceptional tolerability, with no reported worsening of dryness, redness, burning, stinging, itching, swelling, or peeling.

The study was published in the peer-reviewed Journal of Cosmetic Dermatology and is indexed in PubMed.

Yes. Crescel Skin Renewal Cream is specifically designed to be gentle and well tolerated, even on highly sensitive rosacea skin.

Published clinical research demonstrated exceptional tolerability with no reported worsening of redness, dryness, peeling, burning, stinging, itching, or swelling.

Crescel has also earned the National Rosacea Society Seal of Acceptance, recognizing its exceptional tolerability for rosacea-prone skin.

Long-term or frequent use of topical steroid products may contribute to skin barrier damage and, in some individuals, may be associated with topical steroid withdrawal (TSW) after reducing or discontinuing use. Symptoms can include redness, burning, dryness, sensitivity, irritation, and skin flaring.

If you are currently using topical steroid creams, or have used them over an extended period, we recommend consulting your physician or dermatologist before making changes to your skincare routine. They can help guide your individual treatment plan and recovery.

Crescel Skin Renewal Cream is designed to support healthy skin by helping maintain skin hydration, skin barrier function, skin integrity, and overall skin condition through pioneering biobotanical innovation and proprietary microemulsion technology. While Crescel is not intended to treat or cure topical steroid withdrawal syndrome, it may help soothe and support dry, sensitive, and compromised skin as part of a gentle daily skincare routine.

Yes. Crescel Skin Renewal Cream is designed to work in harmony with your skin's natural cellular repair processes and may be used alongside other skincare products.

For best results, apply Crescel to clean, dry skin and allow approximately 10–15 minutes for it to absorb before applying makeup, sunscreen, moisturizers, or other skincare products.

If you are using prescription topical medications or are under the care of a dermatologist or other healthcare provider, we recommend following their guidance regarding your skincare routine.

Crescel Skin Renewal Cream combines pioneering proprietary microemulsion technology with naturally derived botanical ingredients to support the skin's natural cellular repair processes.

Rather than relying solely on the ingredients themselves, Crescel's proprietary microemulsion technology is designed to optimize the delivery of its botanical ingredients where they can best support healthy skin, providing continuous botanical anti-inflammatory and moisturizing support.

Although aloe and oat-derived botanicals have long been recognized for their anti-inflammatory and skin barrier-supporting properties, Crescel's proprietary microemulsion technology is designed to preserve their biological activity while enhancing their synergistic performance. The formulation maintains the skin's natural physiological pH and incorporates both hydrophilic and hydrophobic components that work in harmony with the skin's natural cellular environment.

Together, these innovations create a unique biobotanical technology platform that distinguishes Crescel from conventional skincare products by combining naturally derived botanical science with pioneering proprietary microemulsion technology to support skin hydration, skin barrier function, skin integrity, and overall skin condition.

Yes. Purchasing Crescel Skin Renewal Cream with your HSA or FSA is simple. During checkout, eligible customers can quickly obtain a complimentary Letter of Medical Necessity through our secure Flex integration—making the process easy, convenient, and seamless. Eligibility and reimbursement requirements vary by plan.

No. Crescel Skin Renewal Cream is available without a prescription and can be used as part of your daily skincare routine. If you have a significant skin condition or are under the care of a healthcare provider, we recommend discussing the best approach for your individual needs.

Because Crescel Skin Renewal Cream is a commercially available biobotanical skin health product, insurance coverage may vary depending on your health plan. Crescel is actively pursuing expanded reimbursement opportunities through public and private payers. If you believe Crescel may benefit your skin condition, we encourage you to discuss it with your healthcare provider.